Much Touted “Depression Risk Gene” May Not Add to Risk After All—New Look at Data Confirms Strong Association between Depression and Stressful Life Events

Stressful life events are strongly associated with a person’s risk for major depression, but a certain gene variation long thought to increase risk in conjunction with stressful life events actually may have no effect, according to researchers funded by the NIMH. The study, published in the June 17, 2009, issue of the Journal of the American Medical Association, challenges a widely accepted approach to studying risk factors for depression.

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