Schizophrenia Drugs Raise the Volume of a Key Signaling System in the Brain

All the major groups of medications for schizophrenia turn up the volume of a brain signal known to be muted in individuals with this psychiatric disorder — a signal that also can be influenced by diet. “This is the first example of a common but specific molecular effect produced by all antipsychotic drugs in any biological system,” scientists note in the current edition of ACS Chemical Neuroscience.

Story Source: Adapted from materials provided by American Chemical Society, via EurekAlert!, a service of AAAS.

Journal Reference: Weeks et al. Antipsychotic Drugs Activate the C. elegans Akt Pathway via the DAF-2 Insulin/IGF-1 Receptor. ACS Chemical Neuroscience, 2010; 100325110757056 DOI: 10.1021/cn100010p

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