Adding Electroconvulsive Therapy to Clozapine Improves Drug-Resistant Schizophrenia

Adding electroconvulsive therapy (ECT) to clozapine is an effective treatment for patients with clozapine-resistant schizophrenia, researchers reported at the New Clinical Drug Evaluation Unit 50th Anniversary Meeting.

Clozapine is the drug of last resort for patients with treatment-resistant schizophrenia, but up to 70% of patients do not respond, said lead study author Georgios Petrides, MD, from the Zucker Hillside Hospital, Northshore-Long Island Jewish Health System, Glen Oaks, New York.

“We had nothing that works for these patients. They had failed every medication, and they were on clozapine and even then they had psychotic symptoms,” Dr. Petrides told Medscape Psychiatry. “ECT worked before the advent of medications, but we really didn’t have good studies to prove that it did. This is the first ECT study to be done in this population.”

Reported by Fran Lowry
Medscape Medical News

Submitted by Anna

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