Valproic Acid in Pregnancy Linked to Several Congenital Malformations

A new study confirms that first-trimester exposure to valproic acid is associated with an increased risk for spina bifida compared with no use of antiepileptic drugs or with use of other antiepileptic drugs.

The study also links first-trimester valproic acid exposure to increased risk for 5 other congenital malformations: atrial septal defect, cleft palate, hypospadias, polydactyly, and craniosynostosis.

Reoported Megan Brooks
CME Author: Désirée Lie, MD, MSEd
Medscape Clinical Briefs

submitted by Anna

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