An international study led by University of Montreal scientists suggests family history may not be a good predictor of the presence of mutations predisposing to autism or schizophrenia.
The findings show how new or de novo gene mutations — alterations of the cell’s DNA — play a role in these devastating conditions. Published in the American Journal of Human Genetics, this study has implications for disease prevalence and severity.
The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by University of Montreal
Philip Awadalla et al. Direct Measure of the de novo Mutation Rate in Autism and Schizophrenia cohorts. American Journal of Human Genetics, 2010; DOI: 10.1016/j.ajhg.2010.07.019
Submitted by Anna