Patients’ Own Cells Yield New Insights Into the Biology of Schizophrenia

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After a century of studying the causes of schizophrenia-the most persistent disabling condition among adults-the cause of the disorder remains unknown. Now induced pluripotent stem cells (iPSCs) generated from schizophrenic patients have brought researchers from the Salk Institute for Biological Studies a step closer to a fundamental understanding of the biological underpinnings of the disease.

In their study, published in the April 13, 2011 advance online issue of the journal Nature, the Salk team reports both that neurons generated from these patient-derived iPSCs made fewer connections with each other, and that Loxapine, an antipsychotic drug commonly used to treat schizophrenia, restored neuronal connectivity in iPSC neurons from all patients……

Salk Institute (2011, April 15). Patients’ own cells yield new insights into the biology of schizophrenia. ScienceDaily. Retrieved May 14, 2011, from http://www.sciencedaily.com­ /releases/2011/04/110413132945.htm

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