Researchers have revealed the molecular pathway that is affected during the onset of schizophrenia and successfully alleviated symptoms of the illness in mice, using a commonly used cancer drug.
The research, published online in the journal Brain, is from a group led by Professor Peter Giese at King’s College London, and offers new avenues for drug discovery….
Adapted by ScienceDaily Staff
Reference: O. Engmann, T. Hortobagyi, R. Pidsley, C. Troakes, H.-G. Bernstein, M. R. Kreutz, J. Mill, M. Nikolic, K. P. Giese. Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition. Brain, 2011; DOI: 10.1093/brain/awr155