Columbia University Medical Center researchers have shown that new, or “de novo,” protein-altering mutations — genetic errors that are present in patients but not in their parents — play a role in more than 50 percent of “sporadic” — i.e., not hereditary — cases of schizophrenia.
The findings will be published online on August 7, 2011, in Nature Genetics….
Adapted by ScienceDaily Staff
Reference: Bin Xu, J Louw Roos, Phillip Dexheimer, Braden Boone, Brooks Plummer, Shawn Levy, Joseph A Gogos, Maria Karayiorgou. Exome sequencing supports a de novo mutational paradigm for schizophrenia. Nature Genetics, 2011; DOI: 10.1038/ng.902