Supplementing antipsychotic medication with folate plus vitamin B12 as an adjunctive treatment can improve negative symptoms of schizophrenia, a new study shows.
However, the randomized clinical trial also suggests that the level of treatment response is more significant in individuals with specific gene variants involved in folate metabolism.
“Our finding that folate plus vitamin B12 supplementation can improve negative symptoms opens a new potential avenue for treatment of schizophrenia. Because treatment effects differed based on which genetic variants were present in each participant, the results also support a personalized medical approach to treating schizophrenia,” study investigator Joshua Roffman, MD, said in a release.
By Caroline Cassels, Medscape