FDA Warns Against Valproate to Prevent Migraine in Pregnancy

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The US Food and Drug Administration (FDA) has strengthened warnings against the use of valproate products as a preventive measure against migraine in women who are pregnant.

The new contraindication is based on recently published data from the Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) study showing further evidence that exposure to valproate products during pregnancy can lead to reduced IQ scores in children.

“Valproate medications should never be used in pregnant women for the prevention of migraine headaches because we have even more data now that show the risks to the children outweigh any treatment benefits for this use.”

by Susan Jeffrey

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