High C-Reactive Protein Linked to Late-Onset Schizophrenia

A new study shows a link between elevated levels of C- reactive protein (CRP) and increased risk for late- and very-late-onset schizophrenia.

CRP has previously been linked to increased risk for cardiovascular disease, and more recently, in a study by these same researchers, with risk for depression. In this prospective study, elevated baseline levels of CRP were associated with a significantly increased risk for late-onset and very-late-onset schizophrenia in a general population in Denmark.

“These are novel findings,” the researchers, with lead author Marie Kim Wium-Andersen, MD, from the Department of Clinical Biochemistry at Herlev Hospital and the Copenhagen University Hospital in Denmark, conclude.

“We had up to 19 years of follow-up, and after adjusting for all the other factors that would also increase CRP — smoking, body mass index, alcohol, education, income, diabetes, and all risk factors — we still saw significantly increased risk of schizophrenia; for those who had even very small elevations of CRP, they still have a 6-times increased risk for schizophrenia,” Dr. Wium-Andersen told Medscape Medical News.

by Susan Jeffrey, Medscape

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