A comprehensive review of brain imaging studies provides support for the two main hypotheses regarding the neurobiology of treatment-resistant schizophrenia, namely, “whether treatment- resistant schizophrenia is best understood as a more severe form of responsive schizophrenia or whether it has a fundamentally different pathophysiology,” Robert McCutcheon, MBBS, MRCPsych, told Medscape Medical News.
“Our review shows some support for both of these hypotheses. On some measures, such as gray matter reductions, resistant patients do appear to show more severe abnormalities compared to responsive patients. On other measures examining neurochemical functioning, however, it seems that there can be quite different processes operating in responsive and resistant patients,” Dr McCutcheon explained.
To read the article further, please click here to visit the Medscape website.